CleanAir BioVanguard B6 Cytotoxic Safety Cabinet (Manual Sash, 1.8 m)
Pricing on request
The CleanAir BioVanguard B6 is a large-format cytotoxic safety cabinet for safe preparation of CMR substances and hazardous drugs in GMP pharmaceutical environments.
Certified by TÜV Nord to DIN 12980, it incorporates an additional HEPA filter beneath the worktray that can be replaced while the cabinet remains operational.
Five powerful EBM-Papst EC motors provide exceptional airflow stability and ultra-long HEPA filter lifetime.
The manual sash offers robust, low-maintenance operation for demanding compounding suites.
Ideal for hazardous API handling, oncology pharmacies and cleanroom production areas.
CleanAir BioVanguard B6 – DIN 12980 Certified Cytotoxic Safety Cabinet with Manual Sash
The CleanAir BioVanguard B6 is a 1.80 m wide cytotoxic safety cabinet engineered for the manipulation of hazardous drugs, CMR compounds and potent APIs in GMP pharmaceutical environments. TÜV Nord certification to DIN 12980 confirms compliance with the most demanding European standards for cytotoxic handling.
Based on CleanAir’s proven Class II airflow architecture, the cabinet integrates a critical enhancement: an additional HEPA filtration layer positioned beneath the work surface. This under-worktray filter can be replaced while the cabinet continues operating, allowing uninterrupted workflow and maintaining full operator protection at all times.
During filter replacement, the user remains shielded by the negative-pressure air curtain beneath the front opening. Any released particles are immediately captured by the downflow or exhaust HEPA filters, preventing contamination of the working environment.
Air management is delivered by five oversized German EBM-Papst EC motors in combination with a large, easily accessible prefilter. This configuration produces the longest HEPA filter lifetime in the market and therefore the lowest total cost of ownership over the cabinet’s operational life. Noise, vibration and energy consumption rise only marginally as filters load, a decisive advantage compared with systems using smaller motor platforms.
Electronics designed and manufactured in the Netherlands provide outstanding reliability, minimal downtime and exceptional service life.
Biological containment is reinforced by a double-wall construction under negative pressure, preventing hazardous substances from escaping even in the unlikely event of a structural leak. The V-shaped front intake grille stabilises the protective air curtain and reduces sensitivity to room disturbances, while the sloped rear grille prevents airflow obstruction by the operator.
Seamless internal surfaces and the forward-tilting sash allow rapid and thorough cleaning and decontamination between production campaigns.
Technical specifications – CleanAir BioVanguard B6 Cytotoxic Safety Cabinet (Manual Sash)
| Specification | Biovanguard B6 |
| Work opening (in working position) (h×w) [mm] | 175 × 1790 |
| Maximum work opening height [mm] | 330 |
| External dimensions (excl. exhaust cap) (l×d×h) [mm] | 1985 × 787 × 2262 (1602 + 660) |
| Internal dimensions (l×d×h) [mm] | 1790 × 550/470* × 744** |
| Usable work surface area (b×d) [mm] | 1780 × 400 |
| Weight (excluding stand) [kg] | 400 |
| Air exhaust connection [mm] | Ø 250 |
| Sash | 8 mm laminated glass (2 layers of glass) |
| Front window slope angle | 7° |
Filter configuration
| Filter | Biovanguard B6 |
| Pre-filter [mm] | Coarse filter (ISO 16890) 1760 × 370 |
| Downflow filter [mm] | HEPA 18P4, 457 × 1830 × 93 (mm), H14 acc. EN 1822 |
| Exhaust filter [mm] | HEPA 9P3, 305 × 915 × 117 (mm), H14 acc. EN 1822 |
| 1st HEPA filter | HEPA V-pleats, Type PB-H14, H14 acc. EN 1822 (14 pieces) |
Performance
| Performance | Biovanguard B6 |
| Noise level (according to ISO 11201) [dB(A)] | 56 |
| Average downflow velocity (working mode according to EN 12469) [m/s] | 0.36 ± 0.02 *2a |
| Average downflow velocity (working mode according to c-GMP) [m/s] | 0.45 ± 0.02 *2b |
| Average downflow velocity (stand-by mode) [m/s] | 0.10 – 0.20 |
| Minimum average inflow velocity above the work opening (working mode) [m/s] | ≥ 0.28 *3 |
| Average inflow velocity across the entire work opening (working mode) [m/s] | > 0.5 *3 |
| Air exhaust volume (working mode) ±10% [m³/h] | 525 ± 25 |
Options for CleanAir BioVanguard B6 Cytotoxic Safety Cabinet – Manual Sash
The BioVanguard B6 can be configured with a comprehensive range of GMP-oriented options:
Fixed or electrically height-adjustable base frame
GMP stainless steel stand
Segmented stainless steel worktop (SS304 / SS316)
Additional electrical outlets
Gas, vacuum and compressed-air services
Secure Bunsen burner connection with safety interlock
UV decontamination system
External decontamination port
Exhaust ducting adapter
Non-return damper
Flush-mounted LCD monitor
Data interfaces and monitoring ports
FAT / SAT documentation
IQ / OQ qualification packages