CleanAir BioVanguard B4 Cytotoxic Safety Cabinet (Manual Sash, 1.2 m)
Pricing on request
The CleanAir BioVanguard B4 is a compact cytotoxic safety cabinet for safe handling of hazardous drugs, CMR substances and potent APIs in GMP pharmaceutical environments.
Certified by TÜV Nord to DIN 12980, it features an additional HEPA filter beneath the worktray that can be replaced while the cabinet remains operational.
Three powerful EBM-Papst EC motors ensure exceptional airflow stability and extended HEPA filter lifetime.
The manual sash provides robust, low-maintenance operation in busy compounding suites.
Ideal for oncology pharmacies, hospital cleanrooms and pharmaceutical production areas.
CleanAir BioVanguard B4 – DIN 12980 Certified Cytotoxic Safety Cabinet with Manual Sash
The CleanAir BioVanguard B4 is a 1.20 m wide cytotoxic safety cabinet engineered for the preparation of CMR compounds, hazardous drugs and high-potency APIs in GMP pharmaceutical environments. TÜV Nord certification to DIN 12980 confirms compliance with Europe’s most demanding safety standards for cytotoxic drug handling.
Built on the same advanced airflow principles as CleanAir’s Class II biological safety cabinets, the B4 integrates a critical enhancement: an additional HEPA filtration layer located beneath the work surface. This under-worktray filter can be replaced while the cabinet continues to operate, ensuring uninterrupted workflow and maintaining full operator protection.
During filter replacement, the user remains protected by the negative-pressure air curtain beneath the front opening. Any released particles are immediately captured by the downflow or exhaust HEPA filters, ensuring complete containment.
Air management is delivered by three oversized German EBM-Papst EC motors, paired with a large, easily accessible prefilter. This setup results in the longest HEPA filter lifetime available and delivers the lowest total cost of ownership across the cabinet’s service life. Noise, vibration and energy consumption increase only marginally as filters load.
Electronics developed and manufactured in the Netherlands guarantee outstanding reliability, minimal downtime and long operational life.
Containment performance is further reinforced by the double-wall construction under negative pressure, preventing hazardous substances from escaping even in the unlikely event of a structural failure. The V-shaped front intake grille stabilises the protective air curtain, while the sloped rear grille prevents airflow obstruction by the operator.
Seamless interior finishing and a forward-tilting sash simplify cleaning and decontamination between preparation cycles.
Technical specifications – CleanAir BioVanguard B4 Cytotoxic Safety Cabinet (Manual Sash)
| Specification | Biovanguard B4 |
| Work opening (in working position) (h×w) [mm] | 175 × 1180 |
| Maximum work opening height [mm] | 330 |
| External dimensions (l×d×h) [mm] | 1375 × 787 × 2262 (1602 + 660) |
| Internal dimensions (l×d×h) [mm] | 1180 × 550/470* × 744** |
| Usable work surface area (b×d) [mm] | 1170 × 400 |
| Weight (excluding stand) [kg] | 270 |
| Air exhaust connection [mm] | Ø 250 |
| Sash | 8 mm laminated glass (2 layers of glass) |
| Front window slope angle | 7° |
Filter configuration
| Filter | Biovanguard B4 |
| Pre-filter [mm] | Coarse filter (ISO 16890) 1160 × 370 |
| Downflow filter [mm] | HEPA 12P4, 457 × 1220 × 93 (mm), H14 acc. EN 1822 |
| Exhaust filter [mm] | HEPA 3P6, 305 × 610 × 117 (mm), H14 acc. EN 1822 |
| 1st HEPA filter | HEPA V-pleats, Type PB-H14, H14 acc. EN 1822 (9 pieces) |
Performance
| Performance | Biovanguard B4 |
| Noise level (according to ISO 11201) [dB(A)] | 54 |
| Average downflow velocity (working mode according to EN 12469) [m/s] | 0.36 ± 0.02 *2a |
| Average downflow velocity (working mode according to c-GMP) [m/s] | 0.45 ± 0.02 *2b |
| Average downflow velocity (stand-by mode) [m/s] | 0.10 – 0.20 |
| Minimum average inflow velocity above the work opening (working mode) [m/s] | ≥ 0.28 *3 |
| Average inflow velocity across the entire work opening (working mode) [m/s] | > 0.5 *3 |
| Air exhaust volume (working mode) ±10% [m³/h] | 350 ± 25 |
Options for CleanAir BioVanguard B4 Cytotoxic Safety Cabinet – Manual Sash
The BioVanguard B4 can be equipped with a comprehensive range of GMP-oriented options:
Fixed or electrically height-adjustable base frame
GMP stainless steel stand
Segmented stainless steel worktop (SS304 / SS316)
Additional electrical outlets
Gas, vacuum and compressed-air services
Secure Bunsen burner connection with safety interlock
UV decontamination system
External decontamination port
Exhaust ducting adapter
Non-return damper
Flush-mounted LCD monitor
Data interfaces and monitoring ports
FAT / SAT documentation
IQ / OQ qualification packages