CleanAir BioVanguard B6 Cytotoxic Safety Cabinet (Electrical Sash, 1.8 m)
Pricing on request
The CleanAir BioVanguard B6 is a large-format cytotoxic safety cabinet designed for safe handling of CMR and hazardous drugs in GMP pharmaceutical environments.
Certified by TÜV Nord to DIN 12980, it features an additional HEPA filtration layer beneath the worktray that can be replaced while the cabinet remains operational.
Five powerful EBM-Papst EC motors ensure exceptional airflow stability and extremely long HEPA filter lifetime.
The electrical sash improves ergonomics and procedural compliance in regulated laboratories.
Ideal for hazardous API preparation, oncology pharmacies and cleanroom compounding suites.
Direct successor to the Euroflow B6.
CleanAir BioVanguard B6 – DIN 12980 Certified Cytotoxic Safety Cabinet with Electrical Sash
The CleanAir BioVanguard B6 is a 1.80 m wide cytotoxic safety cabinet engineered for the safe manipulation of hazardous drugs, CMR substances and potent APIs in GMP pharmaceutical environments. It is TÜV Nord certified to DIN 12980 and represents the next generation successor to the Euroflow B6.
Structurally, the cabinet is based on the same advanced airflow concept as CleanAir’s Class II biological safety cabinets, but with the crucial addition of an extra HEPA filter layer located beneath the work surface. This under-worktray filter can be replaced while the cabinet remains in operation, ensuring uninterrupted workflow and maximum operator protection.
During filter replacement, the operator remains protected by the negative-pressure air curtain below the front opening. Any released particles are immediately captured by the downflow or exhaust HEPA filters, maintaining full containment throughout the process.
Air handling is driven by five oversized German EBM-Papst EC motors, combined with a large, easily accessible prefilter. This configuration delivers the longest HEPA filter lifetime on the market and therefore the lowest total cost of ownership over the cabinet’s service life. Even as filters gradually load, noise, vibration and energy consumption increase only minimally compared with systems using smaller motors.
All electronic systems are developed and manufactured in the Netherlands, resulting in outstanding reliability, minimal downtime and an exceptionally long operational lifetime.
Maximum safety is further ensured by the double-wall construction under negative pressure, preventing hazardous substances from escaping in the event of a structural leak. The V-shaped front grille stabilises the protective air curtain and reduces sensitivity to room disturbances, while the sloped rear grille prevents airflow obstruction by the operator.
Seamless internal surfaces and the forward-tilting front sash simplify cleaning and decontamination procedures between production batches.
Technical specifications – CleanAir BioVanguard B6 Cytotoxic Safety Cabinet
| Specification | Biovanguard B6 |
| Work opening (in working position) (h×w) [mm] | 175 × 1790 |
| Maximum work opening height [mm] | 330 |
| External dimensions (excl. exhaust cap) (l×d×h) [mm] | 1985 × 787 × 2262 (1602 + 660) |
| Internal dimensions (l×d×h) [mm] | 1790 × 550/470* × 744** |
| Usable work surface area (b×d) [mm] | 1780 × 400 |
| Weight (excluding stand) [kg] | 400 |
| Air exhaust connection [mm] | Ø 250 |
| Sash | 8 mm laminated glass (2 layers of glass) |
| Front window slope angle | 7° |
Filter configuration
| Filter | Biovanguard B6 |
| Pre-filter [mm] | Coarse filter (ISO 16890) 1760 × 370 |
| Downflow filter [mm] | HEPA 18P4, 457 × 1830 × 93 (mm), H14 acc. EN 1822 |
| Exhaust filter [mm] | HEPA 9P3, 305 × 915 × 117 (mm), H14 acc. EN 1822 |
| 1st HEPA filter | HEPA V-pleats, Type PB-H14, H14 acc. EN 1822 (14 pieces) |
Performance
| Performance | Biovanguard B6 |
| Noise level (according to ISO 11201) [dB(A)] | 56 |
| Average downflow velocity (working mode according to EN 12469) [m/s] | 0.36 ± 0.02 *2a |
| Average downflow velocity (working mode according to c-GMP) [m/s] | 0.45 ± 0.02 *2b |
| Average downflow velocity (stand-by mode) [m/s] | 0.10 – 0.20 |
| Minimum average inflow velocity above the work opening (working mode) [m/s] | ≥ 0.28 *3 |
| Average inflow velocity across the entire work opening (working mode) [m/s] | > 0.5 *3 |
| Air exhaust volume (working mode) ±10% [m³/h] | 525 ± 25 |
Options for CleanAir BioVanguard B6 Cytotoxic Safety Cabinet
The BioVanguard B6 can be configured with a wide range of GMP-focused options, including:
Electrically height-adjustable base frame
GMP stainless steel stand
Segmented stainless steel worktop (SS304 / SS316)
Additional electrical sockets
Gas, vacuum and compressed-air services
Secure Bunsen burner connection with interlock
UV decontamination system
External decontamination port
Exhaust ducting adapter
Non-return damper
Flush-mounted LCD monitor
Data ports (USB / RJ45 / monitoring interfaces)
FAT / SAT documentation
IQ / OQ qualification packages